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Index > Protein center > Irs4(Gene name) > Mouse
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  • Irs4 (Gene name),
  • Insulin receptor substrate 4 (Protein name ),  IRS4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Irs4;
    Protein name:
    Insulin receptor substrate 4(IRS-4);
    Alternative:
    Phosphoprotein of 160 kDa(pp160);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH (By similarity). Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1. Interacts with PIK3R1 and GRB2.
    Function:
    Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Cytoplasmic side
    Protein Attributes:
    Sequence length:
    1216
    Sequence:
    50:
    MASCSFSGHQ | ALRRLRASAA | AAASAALAAV | ATTPLLSSGT | RTALIGTGSS | 
    100:
    CPGAMWLSTA | TGSRSDSESE | EEDLPVGDEV | CKRGYLRKQK | HGHRRYFVLK | 
    150:
    LETADAPARL | EYYRNARKFR | HSVRAAAAAA | EAAASGAAVP | ALIPPRRVII | 
    200:
    LYQCFSVSQR | ADARYRHLIA | LFTQDEYFAM | VAENESEQES | WYLLLSRLIL | 
    250:
    ESKRRRCGTL | GALPDGEPAA | LAAAAAAEPP | FYKDVWQVVV | KPRGLGHRKE | 
    300:
    LSGVFRLCLT | DEEVVFVRLN | TEVASVVVQL | LSIRRCGHSE | QYFFLEVGRS | 
    350:
    TVIGPGELWM | QVDDSVVAQN | MHELFLEKMR | ALCADEYRAR | CRSYSISIGA | 
    400:
    HLLTLLSTRR | HLGLLPLEPG | GWLRRYGLEQ | FCRLRAIRER | EEMLFTRRFI | 
    450:
    SPREPPPPFR | RGRGHLPRAR | RSRRAASVPP | SLFRRSAPSP | GRIPQPEDVP | 
    500:
    NDRAREASGS | SSGNTEEKDK | EGEEGNRGDC | IPMNNWGSGN | GRGSGGGRGS | 
    550:
    SGQGSSSQGS | GGRQGSGGGQ | GSGGQGAGGN | QCSGNGQGTA | GGHGSGGGGH | 
    600:
    GSGGGQRPGD | GHGSGGGKNS | GSGKNSDDGD | RGKSVKKRSY | FGKFTQSKQQ | 
    650:
    QTLPPPPPPP | PAAGATGGKG | KSGGRFRLYF | CADRGTKERK | EAKEVRDMET | 
    700:
    SGGATRGPYR | ARAFDEDEDD | PYVPMRPGVA | APLACSSDYM | PMAPQNSSAS | 
    750:
    TKRHSRSPFE | DSRGYMMMFP | RVSPPPPVPS | APKAPDTNKG | DDSKDNDSDS | 
    800:
    DYMFMAPGAG | AIPKNPPNAQ | GGSSSKSWSS | YFSLPSPFQS | SPLGQSDHSE | 
    850:
    YVPMLPGKFL | GSGLHKEASF | SQGTKNVSSK | PSTEASFSKP | EDKGSSAKPS | 
    900:
    DDVPPMNKAK | EPNHLSFIAK | GTQVKPKPLN | PTQERREAAG | SRDYINIDFI | 
    950:
    KRERLVLPSS | AQGLPDMRGV | VTDPAPTAFS | GYLNVEFGVP | FPNPTIRLSD | 
    1000:
    LLRVLPGANS | IPLAGTRWPF | PGSAIGSIVE | AGEYIEVIFN | PAMTPAMSFA | 
    1050:
    DSAICYDAQT | GQIYVVDPFS | ECCMDVSLSP | GRCSEPPPVA | RLRREEAQER | 
    1100:
    RRPQSRSQSL | FASTRAAVSA | FPTDSLDRDF | PAASAVIAAP | AEAPLLAVSR | 
    1150:
    ALAVVSALAA | APSIGDVFAG | FRAAAGVDSA | SARGFQPVAG | AQAVREFQDL | 
    1200:
    AAGWNPGALN | HRARGEDLAA | GAAAPPPPPR | QIWVLRPQER | ADSEDDDDDD | 
    1216:
    DDIYVRMDFA | RRDYRK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse IRS-4
    Cat.:
    E0288m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse IRS-4
    Cat.:
    E0288h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse IRS-4
    Cat.:
    U0288m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse IRS-4
    Cat.:
    U0288h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse IRS-4
    Cat.:
    P0288Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse IRS-4
    Cat.:
    P0288Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse IRS-4
    Monoclonal Antibody for Mouse IRS-4
    Protein for Mouse IRS-4
    Protein for Mouse IRS-4

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene."
      Fantin V.R. , Lavan B.E. , Wang Q. , Jenkins N.A. , Gilbert D.J. , Copeland N.G. , Keller S.R. , Lienhard G.E.
      Endocrinology140:1329-1337(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
      tissue: Liver.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 746-1216
      strain: C57BL/6J.
      tissue: Embryo.
    4. 4.
      "Insulin receptor substrate 4 supports insulin- and interleukin 4-stimulated proliferation of hematopoietic cells."
      Fantin V.R. , Keller S.R. , Lienhard G.E. , Wang L.-M.
      Biochem. Biophys. Res. Commun.260:718-723(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis."
      Fantin V.R. , Wang Q. , Lienhard G.E. , Keller S.R.
      Am. J. Physiol.278:E127-E133(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION;DISRUPTION PHENOTYPE
    6. 6.
      "Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling."
      Tsuruzoe K. , Emkey R. , Kriauciunas K.M. , Ueki K. , Kahn C.R.
      Mol. Cell. Biol.21:26-38(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PIK3R1 AND GRB2
    7. 7.
      "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation."
      Krebs D.L. , Uren R.T. , Metcalf D. , Rakar S. , Zhang J.-G. , Starr R. , De Souza D.P. , Hanzinikolas K. , Eyles J. , Connolly L.M. , Simpson R.J. , Nicola N.A. , Nicholson S.E. , Baca M. , Hilton D.J. , Alexander W.S.
      Mol. Cell. Biol.22:4567-4578(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOCS6;IDENTIFICATION BY MASS SPECTROMETRY
    8. 8.
      "IRS-4 mediated mitogenic signalling by insulin and growth hormone in LB cells, a murine T-cell lymphoma devoid of IGF-I receptors."
      Ursoe B. , Ilondo M.M. , Holst P.A. , Christoffersen C.T. , Ouwens M. , Giorgetti S. , Van Obberghen E. , Naor D. , Tornqvist H. , De Meyts P.
      Cell. Signal.15:385-394(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PHOSPHATIDYLINOSITOL 3-KINASE;PHOSPHORYLATION
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